GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs11723261 | 1 | rs11248009 | chr4:220149 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs11248013 | chr4:311425 | ZNF718 | chr4:53272-156488:+ | 0.66 | 6.89 | 6.07E-10 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs9815354 | 1 | rs1125203 | chr3:41760895 | ULK4 | chr3:41288091-42003660:- | 1.03 | 11.64 | 5.41E-20 | Diastolic blood pressure |
| THYM | cis | rs3093059 | 1 | rs11265260 | chr1:159700039 | NHLH1 | chr1:160336861-160342638:+ | 0.71 | 4.23 | 5.43E-5 | C-reactive protein |
| THYM | cis | rs17761864 | 1 | rs113333037 | chr17:2200106 | SRR | chr17:2207248-2228553:+ | -0.55 | -5.52 | 2.92E-7 | Esophageal cancer (squamous cell) |
| THYM | cis | rs7969151 | 1 | rs113528355 | chr12:54154515 | COPZ1 | chr12:54718911-54745633:+ | -0.29 | -4.39 | 2.97E-5 | Tanning |
| THYM | cis | rs10935120 | 1 | rs1138273 | chr3:134261437 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.05 | 2.33E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs1138273 | chr3:134261437 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.81 | 8.19E-8 | Height |
| THYM | cis | rs9473555 | 1 | rs1141321 | chr6:49412433 | CENPQ | chr6:49431096-49460820:+ | -0.23 | -4.18 | 6.53E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs1141321 | chr6:49412433 | MUT | chr6:49398994-49431031:- | 0.28 | 4.37 | 3.17E-5 | Folate pathway vitamin levels |
| THYM | cis | rs2143950 | 1 | rs114200987 | chr14:35586916 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.14 | 7.59E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs114200987 | chr14:35586916 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 4.99 | 2.76E-6 | Atopic dermatitis |
| THYM | cis | rs1142345 | 1 | rs1142345 | chr6:18130918 | NHLRC1 | chr6:18120718-18122851:- | -1.1 | -4.37 | 3.12E-5 | Thiopurine methyltransferase activity in acute lymphoblastic leukemia patients treated with mercaptopurines |
| THYM | cis | rs8050907 | 1 | rs114914341 | chr16:4617621 | NMRAL1 | chr16:4511696-4526307:- | -0.5 | -5.61 | 1.96E-7 | Obesity-related traits |
| THYM | cis | rs9815354 | 1 | rs114960066 | chr3:41882323 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |